Other names:
Pentadecapeptide, Body Protection Compound, Body Protection Complex. PL14736, PL-10, Bepecin.

Actions:
Accelerates Healing, Analgesic, Anti-Inflammatory, Anti-Anastomotic, Angiogenesis/Blood Vessel Growth, Bone and Joint Health, Brain Health, Burn Healing, Healing Gastric Ulcers, Hepatoprotective, Immune System Modulation, Intestinal Epithelium Restorative, Neuroprotective, Neurotransmitter Modulation, Neuroplasticity, Nitric Oxide Generation, Nootropic, Tight junction Repair, Reflux, Wound Healing.

Conditions:
Broken/Fractured Bones, Brain Damage, Brain Fog, Carpal Tunnel, Celiac Disease, Colitis, Crohn’s Disease, Endometriosis, Gastric Reflux, IBS, Leaky-gut, Ligament Injury, Multiple Sclerosis, PCOS, Periodontal disease, Stomach Ulcers, Tendonitis, Tendon Injury.

Overview:
BPC157 is a peptide that is naturally found in human gastric acid secretions, it works by enhancing your body’s natural healing processes and thereby speeding up the rate of recovery from injury.This peptide has been studied for decades and has demonstrated multiple and diverse benefits including:

Mechanisms:

  • Stimulates EGR-1 (Early growth factor protein) / Nerve growth factor-induced protein.
  • Stimulates Angiogenesis via upregulation and increased activity of VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) to allow the body to build blood vessels to deliver oxygen, nutrients and remove metabolic waste.
  • Enhances Growth Hormone receptors, especially on ligaments and tendons.

Details and History:

ВРС-157 іѕ a fascinating соmроund that іѕ іnсrеаѕіnglу being іnvеѕtіgаtеd and used for іtѕ еffесtѕ in healing and repairing tіѕѕuеs, аѕ wеll аѕ іn а wіdе vаrіеtу оf health conditions including nеurоlоgісаl, іnflаmmаtоrу аnd аutоіmmunе dіѕеаѕеѕ.

It was first studied in rat models to heal gastric ulcers, it was found to be orally bioavailable because it is naturally found in the stomach, this means unlike other peptides or hormones such as insulin or testosterone that need to be injected, BPC can be taken orally without the stomach acid denaturing or degrading the functional structure of the peptide.

Because this peptide is found in the human gastrointestinal tract, it is considered a natural compound, therefore, is not patentable, therefore not financially viable for drug companies to invest in, this is likely why this peptide has not become a staple in medical practice and is still in the fringe of biohacking, functional and longevity medicine.

The main indications for BPC-157 are accelerating ligament and tendon injury recovery and repairing leaky-gut / reducing intestinal permeability. BPC is so beneficial for the gastrointestinal tract that it is currently in phase III and IV human trials for the autoimmune inflammatory bowel diseases Ulcerative Colitis and Crohn’s disease.

Intestinal permeability, or “leaky gut,” is an extremely common issue that allows bacterial toxins such as LPS and other harmful compounds in our guts to directly enter our bloodstream causing inflammation and putting pressure on our immune system and detoxification organs. There are plenty of different supplements and protocols aimed at healing leaky gut, but BPC-157 is has been toted by many as the best compound at addressing this issue.

BPC-157’s main mechanism of action is improving angiogenesis – the process by which new blood vessels are created. BPC improves blood flow in wounded and damaged areas of your body through the process of enhanced angiogenesis. It also improves healing by upregulating growth hormone receptors. Additionally, it increases the activity and upregulation of critical healing factors such as EGR-1, NGF, and VEGF.


Technical Information:

Body Protective Compound: BPC-157 is a peptide chain consisting of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala- Gly-Leu-Val) with a molecular formula of 62 carbons, 98 hydrogens, 60 nitrogen and 22 oxygen atoms.

Oral BPC comes in both acetate and arginine salt; Regenerate uses the highly bioavailable arginine salt version.
The less efficacious acetate salt version commonly found in inferior quality products and from foreign suppliers. The arginine salt version is characterized by increased resistance to gastric juice and high temperatures. All this means that the BPC can pass through the stomach unchanged where it can then be absorbed in the intestines, as such BPC-Arginine is a competitive alternative to injectable preparations.

Researchers have conducted numerous rodent studies on BPC-157 that show it a multitude of protective effects on the organism.
BPC-157 has been shown to benefit ulcers in the stomach, intestinal damage such as fistulas and inflammatory disorders, bone and joint healing and growth rates, and organ damage.

BPC-157 is also capable of healing detached or disjoined Achilles tendon. (Staresinic et al. 2003).
In particular, one study found BPC-157 to be effective in healing quadriceps muscles that have been torn and crushed. Butler et al. (2007). Muscle tears have also been observed to recover much faster with BPC-157 administration, even when the healing process is impaired by the systemic use of corticosteroids. (Gwyer et al. 2019) (Pevec et al. 2010).

Image Reference: Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. https://www.ncbi.nlm.nih.gov/pubmed/20190676.

Ligaments: BPC-157 can lead to superior healing of damaged ligaments, along with tendon-to-bone healing. A rat study conducted in 2010 found that BPC-157 led to the healing of acute ligament injuries within rats.

It also has some influences on the brain and neurochemistry (dopaminergic and serotonergic actions) as well as helping reduce neurological inflammation.
Researchers have observed marked protective effects when BPC-157 is administered to rats alongside a research toxin or damaging surgical procedure.

Similarly to how BPC can assist in repairing the gut barrier, it may also elicit the same beneficial effect on the blood brain barrier (BBB).
Reducing BBB hyper-permeability is key to reducing neurological inflammation and keeping out toxins such as circulating heavy metals, hormones and other chemicals that should not entry to the brain.

BPC-157 has multiple mechanisms of action, but current research suggests BPC-157 influences several growth factors usually involved in angiogenesis (the production of blood vessels) and other factors involved in regeneration following damage.

BPC will heal what the body wants to heal most, not always what we want it to heal, so taking BPC with the expectation for it to heal a specific injury may not actually work. If there is a lot of gastrointestinal damage, the body will repair first according to its own needs and priority.
BPC is considered a smart peptide in that it goes where it is needed; damaged areas in the body and sites of inflammation characterised by

BPC in Sports:
As of the date of this blog article publication, BPC 157 is presently NOT listed as an illegal compound by WADA or ASADA.


Dosing:
Oral: 250-1000 mcg/day for 30days; continue if improvements noticed. Dose-dependent on purpose. High doses for enhanced injury recovery may be warranted.

Split doses: 250mcg morning, 250mcg night is a good dosing protocol and to keep in circulation.

Side effects:
BPC is an effective formula designed to protect and heal your body, without harmful side effects.

Oral: None known; however more research is needed.

All studies have shown it has fewer side effects than placebo and there have been no adverse or negative reactions reported in the few trials conducted on human beings. However, there is a need for further peer-reviewed trials.

Injectable: can result in pain and redness around the injection site as well as potential histamine reactions after prolonged use.

LD50:
>125g (80kg human). Eq: 250,000 x the supplemental dose; Huge therapeutic window.

Contraindications:
Cancer; Angiogenesis and VEGF are drivers of cancer growth.

Interactions:
As BPC is not metabolised by the liver (broken down is circulation by hydrolase enzymes) thus, there are no established drug-interactions.


Other Mechanisms of action:

  • Increases c-Fos R
  • Increases c-Jun R
  • Increases Collagen R
  • Increases COX-1 R
  • Increases COX-2 R
  • Increases EGR-1 R
  • Increases EPAC2 R
  • Increases ERK1/2 R
  • Increases eNOS R
  • Increases FAK R
  • Increases GH R
  • Increases HP33 R
  • Increases iNOS R
  • Increases Jak2 R
  • Increases KCNC2 R
  • Increases MDA R
  • Increases NAB2 R
  • Increases NO R
  • Increases Paxillin R
  • Increases RBBP9 R
  • Increases Selectin E R
  • Increases SLC26 R
  • Increases VEGFR2 R R
  • Increases V2R R
  • Increases WISP1 R
  • Reduces BMP4 R
  • Reduces Leptin R
  • Reduces LTB4 R
  • Reduces MPO R
  • Reduces TXB2 R
  • Reduces VCAM1 R
  • Reduces 5HT2A R

FREE FULL DOWNLOADS OF BPC STUDIES AVAILABLE HERE

General:
-BPC-157s-effect-on-healing
A new gastric juice peptide BPC. An overview of the stomach stress organoprotection hypothesis and beneficial effects of BPC

Gastrointestinal:
-The influence of a novel pentadecapeptide, BPC 157, on N G-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure
-Focus on Ulcerative Colitis- Stable Gastric Pentadecapeptide BPC 157
-Novel Pharmacologic Approaches to the Prevention and Treatment of Ulcerative Colitis
Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats- New insights

Musculoskeletal:
-Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing
-Effective Therapy of Transected Quadriceps Muscle in Rat:Gastric Pentadecapeptide BPC 157
-Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application

Ligaments/Tendons/Collagen
-Pentadecapeptide BPC 157 (PL 14736) Improves Ligament Healing in the Rat
-Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression
-Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth

Nervous system:
-Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury
-Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats
-Brain-gut-Axis-and-Pentadecapeptide-BPC-157-Theoretical-and-Practical-implications

Periodontal disease:
-Antiinflammatory effect of BPC 157 on experimental periodontitis in rats

Cardiovascular:
-Doxorubicine-Congestive Heart Failure-Increased Big Endothelin-1 Plasma Concentration- Reversal by Amlodipine, Losartan, and Gastric Pentadecapeptide BPC157 in Rat and Mouse


REFERENCES:

Butler, R. J., Marchesi, S., Royer, T., & Davis, I. S. (2007). Effective Therapy of Transected Quadriceps Muscle in Rat:Gastric Pentadecapeptide BPC 157. Journal of Orthopaedic Research September, 25(June), 1121–1127. https://doi.org/10.1002/jor

Brcic, L., Brcic, I., Staresinic, M., Novinscak, T., Sikiric, P., & Seiwerth, S. (2009). Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society, 60 Suppl 7, 191–196.

Cerovecki, T., Bojanic, I., Brcic, L., Radic, B., Vukoja, I., Seiwerth, S., & Sikiric, P. (2010). Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. Journal of Orthopaedic Research, 28(9), 1155–1161. https://doi.org/10.1002/jor.21107

Chang, C. H., Tsai, W. C., Hsu, Y. H., & Pang, J. H. S. (2014). Pentadecapeptide bpc 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules, 19(11), 19066–19077. https://doi.org/10.3390/molecules191119066

Chang, C. H., Tsai, W. C., Lin, M. S., Hsu, Y. H., & Su Pang, J. H. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 110(3), 774–780. https://doi.org/10.1152/japplphysiol.00945.2010

Gjurasin, M., Miklic, P., Zupancic, B., Perovic, D., Zarkovic, K., Brcic, L., … Sikiric, P. (2010). Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury. Regulatory Peptides, 160(1–3), 33–41. https://doi.org/10.1016/j.regpep.2009.11.005

Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, 377(2), 153–159. https://doi.org/10.1007/s00441-019-03016-8

Perovic, D., Kolenc, D., Bilic, V., Somun, N., Drmic, D., Elabjer, E., … Sikiric, P. (2019). Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. Journal of Orthopaedic Surgery and Research, 14(1), 1–12. https://doi.org/10.1186/s13018-019-1242-6

Pevec, D., Novinscak, T., Brcic, L., Sipos, K., Jukic, I., Staresinic, M., … Sikiric, P. (2010). Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. Medical Science Monitor, 16(3), 81–88.

Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., … Kolega, Z. (1997). BPC 157’s effect on healing. Journal of Physiology Paris, 91(3–5), 173–178. https://doi.org/10.1016/S0928-4257(97)89480-6

Sever, A. Z., Sever, M., Vidovic, T., Lojo, N., Kolenc, D., Vuletic, L. B., … Sikiric, P. (2019). Stable gastric pentadecapeptide BPC 157 in the therapy of the rats with bile duct ligation. European Journal of Pharmacology, 847(January), 130–142. https://doi.org/10.1016/j.ejphar.2019.01.030

Sikiric, P. (1999). The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacology, 7(1), 1–14. https://doi.org/10.1007/s10787-999-0022-z

Sikirić, P., Petek, M., Ručman, R., Seiwerth, S., Grabarević, Z., Rotkvić, I., … Karakas, I. (1993). A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC. Journal of Physiology – Paris, 87(5), 313–327. https://doi.org/10.1016/0928-4257(93)90038-U

Sikiric, P., Seiwerth, S., Kolenc, D., Grgić Klinička bolnica, T., Duh, S., Rucman, R., … Vlainic, J. (2018). Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications Article in DNA research: an international journal for rapid publication of reports on genes and genomes · May 2016 CITATIONS 12 READS 793 Genetic and epigenetic biomarkers of innate immunity in COPD and lung cancer View project BPC 157 View project Send Orders for Reprints to reprints@benthamscience.ae, 857–865. https://doi.org/10.2174/1570159X13666160502153

Staresinic, M., Sebecic, B., Patrlj, L., Jadrijevic, S., Suknaic, S., Perovic, D., … Sikiric, P. (2003). Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. Journal of Orthopaedic Research, 21(6), 976–983. https://doi.org/10.1016/S0736-0266(03)00110-4

Other resources and information:

https://www.youtube.com/watch?v=IQNw97xKTk4

https://www.youtube.com/watch?v=qhqrusMfH4U

https://www.youtube.com/watch?v=YwBf-Ny9XQU

https://www.vitamonk.com/blogs/health/bpc-157-overview

https://mybiohack.com/blog/bpc-157-pl-14736-pl-10-pld-116